认知功能与疾病研究室
李葆明
马朝林
潘海莉
罗飞
孙翀
罗洁
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认知功能与疾病研究室

研究内容:

      实验室聚焦于前额叶皮层认知功能与疾病的基础研究,同时开展相关领域的多学科交叉研究。主要研究方向包括:

1)学习记忆的脑机制

2)前额叶的认知功能

3)多动症的神经机制


 

研究贡献:

1)发现大脑前额叶a2A受体与多动症的关系

2)解析了β受体在记忆巩固中的作用及机制

3)鉴定了3个参与学习记忆的海马新基因

4)解析了工作记忆、联合学习的神经元编码




代表性研究论文:

    1. Wang Q, Yang ST, Li BM*. Neuronal representation of audio-place associations in the medial prefrontal cortex of rats. Mol. Brain. 2015, 8 (1), 56.

2. Yang ST, Shi Y, Wang Q, Peng JY, Li BM*. Neuronal representation of working memory in the medial prefrontal cortex of rats. Mol. Brain. 2014, 28 (7), 61.

3. Yi F, Zhang XH, Yang CR, Li BM*. Contribution of dopamine d1/5 receptor modulation of post-spike/burst afterhyperpolarization to enhance neuronal excitability of layer v pyramidal neurons in prepubertal rat prefrontal cortex. PLoS One. 2013, 8(8), e71880.

4. Yi F, Liu SS, Luo F, Zhang XH, Li BM*. Signaling mechanism underlying α2A-adrenergic suppression of excitatory synaptic transmission in the medial prefrontal cortex of rats. Eur J Neurosci. 2013, 38 (3):2364-73.

5. Ji XH, Ji JZ, Zhang H, Li BM*. Stimulation of alpha2-adrenoceptors suppresses excitatory synaptic transmission in the medial prefrontal cortex of rat. Neuropsychopharmacology, 2008, 33(9): 2263-71.

6. Ji XH, Cao XH, Zhang CL, Feng ZJ, Zhang XH, Ma L, Li BM*. Pre- and postsynaptic beta-adrenergic activation enhances excitatory synaptic transmission in layer V/VI pyramidal neurons of the medial prefrontal cortex of rats. Cereb Cortex. 2008, 18 (7): 1506-20.

7. Zhao MG, Toyoda H, Lee YS, Wu LJ, Ko SW, Zhang XH, Jia Y, Shum F, Xu H, Li BM*, Kaang BK*, Zhuo M*. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. 2005. 47 (6): 859-72.

8. Ma CL, Arnsten AF, Li BM*. Locomotor hyperactivity induced by blockade of prefrontal cortical alpha2-adrenoceptors in monkeys. Biol Psychiatry. 2005. 57 (2): 192-5.

9. Arnsten AF*, Li BM*. Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions. Biol Psychiatry. 2005. 57 (11): 1377-84.

10. Wang M, Ji JZ, Li BM*. The alpha (2A)-adrenergic agonist guanfacine improves visuomotor associative learning in monkeys. Neuropsychopharmacology. 2004. 29 (1): 86-92.

11. Mao ZM, Arnsten AF, Li BM*. Local infusion of an alpha-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys. Biol Psychiatry. 1999. 46 (9): 1259-65.

12. Li BM*, Mao ZM, Wang M, Mei ZT. Alpha-2 adrenergic modulation of prefrontal cortical neuronal activity related to spatial working memory in monkeys. Neuropsychopharmacology. 1999. 21 (5): 601-10.




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