兼职科研人员
James Dempsey Fraser
王小强
吴小平
夏 斌
葛 刚
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王小强

王小强,美籍、江西景德镇人,博士,美国SRNF植物研究所教授。主要从事植物蛋白结构与功能的多样性、蛋白质生物工程研究。曾任抗菌研究国际会议的国际科学顾问委员会成员等学术任职,担任美国国家科学基金会评审专家,并为重要学术刊物评审专家,如PNAC. PLoS BiologyPlant Cell Mol. Biol. J. General VirologyAnti-Cancer Agents in Medicinal Chemistry Acta Crystallographica等;发表SCI刊物论文40余篇,主要有:Cell, Science, Plant Cell, Proc. Natl. Acad. Sci. USANature Structural Biology等国际一流的学术论文,论文被引用1000多次。

2012年受聘为南昌大学特聘讲座教授,获得江西省“赣鄱英才555工程”高端人才柔性特聘计划项目资助。

      Plant Biology DivisionSamuel Roberts Noble Foundation2510 Sam Noble ParkwayArdmore OK 73401, USA

Email: xwang@noble.org

 

教育经历:

1983.9-1987 .7                武汉大学 ,化学 ,本科生

1987.9-1990 .7                武汉大学 ,化学, 硕士生

1990.10-1993.11             中国科学院生物物理所,生物学,博士生 

 

工作与科研经历:

1993.11-1995.12            中国科学院生物物理所,助理研究员 / 副研究员

1995.12-1996.12            英国Manchester 大学,博士后

1996.12-1999.08            美国 Oklanhoma Medical Reserch Foundation,博士后

1999.08-2002.03            美国NIH / NIEHS ,博士后

2002.03-现在                  美国Samuel Roberts Noble Foundation 结构生物学实验室主任 ,助理教授 / 副教授 /教授

 

主要科研项目:

1.        Wang, X. (PI), Dixon, R.A. (Co-PI), Biosynthesis of isoflavonoids: structure, mechanism and engineering (National Science Foundation)

2.        Wang, X. (PI), Dixon, R.A. (Co-PI), National Science Foundation, 2004-2008, Structural and functional studies of plant natural product uridine diphosphate glycosyltransferases.

3.        Wang, X. (PI), Young Scientist Grant, National Natural Science Foundation of China, 1995-1997, Crystallographic studies of inhibited and calcium-free phospholipase A2 from the venom of Agkistrodon halys pallas.

4.        Wang, X. (PI), Molecular and structural basis of plant biomass lignin biosynthesis. Oklahoma Center for the Advancement of Science and Technology, 2011-2013

 

学术服务:

1.        Manuscripts reviewed for the following journals: Proc. Natl. Acad. Sci. USA.;  PLoS Biology; Plant Cell; J. Mol. Biol.; J. General Virology;  Anti-Cancer Agents in Medicinal Chemistry; Acta Crystallographica;  Molecules; Biochimica et Biophysica Acta; Archives of Microbiology;  Journal of Molecular Catalysis B: Enzymatic

2.        Grant proposals reviewed for the National Science Foundation

3.        Synchrotron user proposals reviewed for the Advanced Photon Source, Argonne National Laboratory

4.        Member of the International Scientific Advisory Committee for the International Conference on Antimicrobial Research (ICAR2010, Valladolid, Spain)

5.        Crystallography workshop for the Noble Scholars, Noble summer interns and teachers in the Noble-Oklahoma Science Project, July, 2005, 2006, 2007.

 

近几年学术论文:

1.    Cheng, X., Wang, X., Wu, J., Briddon, R.W., Zhou, X. (2011). βC1 encoded by tomato yellow leaf curl China betasatellite forms multimeric complexes in vitro and in vivo. Virology. 409, 156-162.

2.   Wang, X. (2011). Structure, function and engineering of enzymes in isoflavonoid biosynthesis. Functional & Integrative Genomics. 11, 13-22.

3.   Wang, X. (2010). Structural studies and mechanisms of isoflavonoid biosynthesis. In: Isoflavones Biosynthesis, Occurence and Health Effects, Thompson, M.J., eds (Nova Science Publishers), pp. 239-254

4.   Li, L., Cheng, N., Hirschi, K.D., Wang, X. (2010). Crystal structure of Arabidopsis chloroplastic monothiol glutaredoxin AtGRXcp.  Acta Crystallographica. D66, 725-732.

5.   Morgan, R.L., Zhou, H., Lehto, E., Nguyen, N., Bains, A., Wang, X., Ma, W. (2010). The catalytic domain of the diversified Pseudomonas syringae type III effector HopZ1 determines their allelic specificities in plant hosts. Molecular Microbiology, 76, 437-455.

6.   Wang, X. (2009). Structure, mechanism and engineering of plant natural product glycosyltransferases. FEBS Letters 583, 3303-3309.

7.   Modolo, L.V., Li, L., Pan, H., Blount, J.W., Dixon, R.A., Wang, X. (2009). Crystal structures of glycosyltransferase UGT78G1 reveal the molecular basis for glycosylation and deglycosylation of (iso)flavonoids. J. Mol. Biol. 392, 1292-1302.

8.   Modolo, L.V., Escamilla-Trevino L.L., Dixon, R.A., Wang, X. (2009). Single amino acid mutations of Medicago glycosyltransferase UGT85H2 enhance activity and impart reversibility. FEBS Letters 583, 2131-2135.

9.   Li, L., Chang, Z., Pan, Z., Fu, Z., Wang, X. (2008). Modes of heme-binding and substrate access for cytochrome P450 CYP74A revealed by crystal structures of allene oxide synthase. Proc. Natl. Acad. Sci. USA. 105, 13883-13888.

10.  Chang, Z., Li, L., Pan, Z., Wang, X. (2008). Crystallization and preliminary X-ray analysis of allene oxide synthase, cytochrome P450 CYP74A2 from Parthenium argentatum. Acta Crystallographica. F64, 668-670.

11.   Pan, H., Wang, Y., Zhang, Y., Zhou, T., Fang, C., Nan, P., Wang, X., Li, X., Wei, Y., & Chen, J. (2008). Phenylalanine ammonia lyase functions as a switch directly controlling the accumulation of calycosin and calycosin-7-O-beta-D-glucoside in Astragalus membranaceus var. mongholicus plants. Journal of Experimental Botany, 59, 3027-3037.

12.     Shao, H., Dixon, R.A., Wang, X. (2007). Crystal structure of vestitone reductase from Alfalfa (Medicago sativa L.). J. Mol. Biol. 369, 265-276.

13.     Li, L., Modolo, L.V., Escamilla-Trevino L.L., Achnine, L., Dixon, R.A., Wang, X. (2007). Crystal structure of Medicago truncatula UGT85H2 - Insights into the structural basis of a multifunctional (iso)flavonoid glycosyltransferase. J. Mol. Biol. 370, 951-963.

14.     Modolo, L.V., Blount, J.W., Achnine, L., Naoumkina, M.A., Wang, X., Dixon, R.A. (2007). A functional genomics approach to (iso)flavonoid glycosylation in the model legume Medicago truncatula. Plant Molecular Biology 64, 499-518.

15.     He, X., Wang, X., Dixon, R.A. (2006). Mutational analysis of the Medicago glycosyltransferase UGT71G1 reveals residues that control regio-selectivity for (iso)flavonoid glycosylation. J. Biol. Chem. 281, 34441-34447.

16.     Wang, X., He, X., Lin, J., Shao, H., Chang, Z., Dixon, R.A. (2006). Crystal structure of isoflavone reductase from Alfalfa (Medicago sativa L.). J. Mol. Biol. 358, 1341-1352.

17.     Shao, H., He, X., Achnine, L., Blount, J.W., Dixon, R.A., Wang, X. (2005). Crystal structures of a multifunctional triterpene/flavonoid glycosyltransferase from Medicago truncatula. Plant Cell 17, 3141-3154.


近几年受邀学术会议及学术报告:

1.        Dept. of Biology, Texas Woman’s University, Denton, TX, March, 2011 (Talk)

2.    American Association of Pharmaceutical Scientists (AAPS) University of Houston Chapter, Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX, November 2010 (Talk)

3.        Vth International Congress on Legume Genetics and Genomics, Pacific Grove, California, July 2010 (Talk)

4.        2010 Enzymes, Coenzymes & Metabolic Pathways Gordon Research Conference, Waterville Valley, New Hampshire, July 2010

5.        The 55th Annual Oklahoma Pentasectional Meeting of the American Chemical Society, Norman, Oklahoma, April 2010 (Talk)

6.        2009 American Crystallographic Association Annual Meeting, Toronto, Canada, July 2009 (Talk)

7.     Dept. of Biochemistry and Molecular Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, February, 2009 (Talk)

8.        2009 Glycobiology Gordon Research Conference, Ventura, California, January 2009 (Talk)

9.        Dept. of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, September, 2008 (Talk)

10.     XXI Congress and Assembly of the International Union of Crystallography, Osaka, Japan, August 2008

11.     The 22nd Symposium of the Protein Society, San Diego, CA, July, 2008

12.     2007 American Crystallographic Association Annual Meeting, Salt Lake City, Utah,  July, 2007

13.     The 18th International Conference on Arabidopsis Research, Beijing, China, June 2007

14.     Center for Plant Cell Biology, University of California at Riverside, March, 2007 (Talk)

15.     2006 American Society of Plant Biologists Annual Meeting, Boston, MA, August 2006


 

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