焦虑与恐惧障碍研究室
潘秉兴
许晓彬
张文华
刘志鹏
实验室学生
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张文华

张文华,男,1984年6月出生,博士,助理研究员,主要从事慢性应激导致焦虑障碍的神经机制研究。

教育经历

2007/09 – 2014/06  华中科技大学,生物化学与分子生物学专业,博士

2003 /09– 2007/06  西南大学, 生物科学专业,学士

工作经历

2014/07 – 至今    南昌大学,生命科学研究院,助理研究员

发表论文

1.       Wenhua Zhang, Chanjuan Xu, Haijun Tu, Yunyun Wang, Qian Sun, Ping Hu, Yongjian Hu, Philippe Rondard, Jianfeng Liu. GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Scientific Reports, 2015, 5:10468 

2.       Zongyong Zhang*, Wenhua Zhang*, Siluo Huang*, Qian Sun, Yunyun Wang, Yongjian HU, Ninghua Sun, Yilei Zhang, Zhihua Jiang, Li Su, Jianfeng Liu. GABAB receptor promotes its own surface expression by recruiting a Rap1-dependent          signaling cascade. Journal of cell science, 2015, 128:2302-2313 (*co-first authors) 

3.       Min Wan*, Wenhua Zhang*, Yangli Tian, Chanjuan Xu, Tao Xu, Jianfeng Liu, Rongying Zhang. Unraveling a molecular determinant for clathrin-independent internalization and subsequent degradation of M2 mAChR. Scientific Reports, 2015,              5:11408(*co-first authors)  

4.       Chanjuan Xu, Wenhua Zhang, Philippe Rondard, Jean Philippe Pin, Jianfeng Liu. Complex GABAB receptor complexes: how to generate multiple functionally distinctunits from a single receptor. Frontiers in Neuropharmacology. 2014; 

5.       Ping Hu, Bin Li, Wenhua Zhang, Yijian Li, Guang Li, Xinnong Jiang, Joanna Wdzieczak-Bakala, and Jianmiao Liu. AcSDKP regulates cell proliferation through PI3KCA/Akt signaling pathway. PLoS ONE, 2013, 8(11): e79321

6.       Guillaume A. Baloucoune*, Lei Chun*, Wenhua Zhang*, Chanjuan Xu, Siluo Huang, Qian Sun, Yunyun Wang, Haijun Tu, and Jianfeng Liu. GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R                    transactivation. PLoS ONE, 2012, 7(6):e39698(*co-first authors)

7.       Chun Lei, Zhang Wenhua, Liu Jianfeng. Structure and ligand recognition of Class C GPCR. Acta Pharmacol.Sin, 2012, 33:312-323

8.       Xin Lin*, Xin Li*, Ming Jiang*, linhai Chen*, Chanjuan Xu, Wenhua Zhang, Han zhao, Bing Sun, Xiaoli Xu, Fajun Nan, Jianfeng Liu. An activity-based probe reveals dynamic protein-protein interactions mediate IGF-1R transactivation by GABAB receptor      in neurons. Biochem J, 2012, 443.627-634 

9.       Haijun Tu*, Chanjuan Xu*, Wenhua Zhang, Qiuyao Liu, Philippe Rondard, Jean-Philippe Pin, Jianfeng Liu. GABAB receptor activation protects neurons from apoptosis via IGF-I receptor transactivation. J Neurosci. 2010, 30(2):749-59 

10.    张文华,孙倩,胡勇箭,刘剑峰. GABAB受体与跨膜受体交叉对话研究新进展.生物物理学报,2013; 29 (10).714-723(封面文章)

11.    张文华,王云云,丁明柳,刘剑峰. GABA受体与脆性X染色体综合征研究新进展.生物物理学报,2013; 29 (11).793-800

12.   蒋明, 黄思罗, 林昕, 春雷, 皮振钧, 孙兵, 张文华, 赵菡, 刘剑峰. GABAB 受体变构剂药学研究进展.现代生物医学进展, 2011; 14.2775-04

专利

1.       发明专利:一种细胞模型及其构建方法和在筛选抗神经紊乱性疾病药物中的应用。发明人:刘剑峰,张文华,孟夏,皮振钧,胡萍,孙兵。专利号:ZL201210394298.X

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